Brain Defenders: How to Protect Your Brain for Life

David Perlmutter

Aug 2026 · Hachette UK

Ebook

384

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INSTANT NEW YORK TIMES BESTSELLER

'A science-based, actionable blueprint to shift the brain from decline to repair.' ― Dr David Sinclair, New York Times bestselling author of Lifespan

A ground-breaking new book from the bestselling author Dr David Perlmutter that will transform our understanding and treatment of degenerative brain diseases.

In recent years microglia cells housed in the brain have been identified as playing a key role in a host of neurodegenerative diseases such as Alzheimer's, Parkinson's, Long Covid, and MS amongst others. When operating optimally, these cells support healthy brain function. However, when they go rogue, they cause inflammation in the brain, contributing to cell death and devastating neurological conditions.

Current drug treatments mostly mask symptoms rather than cure and the statistics are grim: worldwide, 55 million people suffer from Alzheimer's, 10 million people have been diagnosed with Parkinson's, and serious neurological disorders are on a rapid rise.

And the good news? By following the lifestyle protocol that Dr David Perlmutter presents in the book people can become 'architects of their cognitive destiny'. The Brain Defenders program is accessible to all and will help us start to win the war against the scourge of neurodegenerative diseases.

INSTANT NEW YORK TIMES BESTSELLER 'A science-based, actionable blueprint to shift the brain from decline to repair.' ― Dr David Sinclair, New York Times bestselling author of Lifespan A ground-breaking new book from the bestselling author Dr David Perlmutter that will transform our understanding ...

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About the author

Dr David Perlmutter is a board-certified neurologist and Fellow of the American College of Nutrition. He is a frequent lecturer at institutions including the World Bank, Columbia University, New York University, Yale, and Harvard, and is the recipient of numerous awards. Dr Perlmutter is the author of Grain Brain, Brain Maker, The Grain Brain Whole Life Plan, The Grain Brain Cookbook and Brain Wash.

Dr David Perlmutter is a board-certified neurologist and Fellow of the American College of Nutrition. He is a frequent lecturer at institutions including the World Bank, Columbia University, New York University, Yale, and Harvard, and is the recipient of numerous awards. Dr Perlmutter is the auth...

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